RT Book, Section A1 Baldini, Elizabeth H. A2 Sugarbaker, David J. A2 Bueno, Raphael A2 Colson, Yolonda L. A2 Jaklitsch, Michael T. A2 Krasna, Mark J. A2 Mentzer, Steven J. A2 Williams, Marcia A2 Adams, Ann SR Print(0) ID 1105845142 T1 Radiation Therapy for Mesothelioma T2 Adult Chest Surgery, 2e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-178189-3 LK accesssurgery.mhmedical.com/content.aspx?aid=1105845142 RD 2024/10/08 AB Treatment of malignant pleural mesothelioma with radiation therapy (RT) is extremely challenging. The target volume for treatment is very large, involving almost the entire hemithorax, and within and adjacent to this treatment volume, there are many normal structures with low tolerances to radiation. Consequently, it is very difficult to create treatment plans that deliver satisfactorily high doses to the complex target volume yet minimal doses to the adjacent radiosensitive normal organs. This chapter will review the history, current approaches, and future ideas for the treatment of pleural mesothelioma with radiotherapy in definitive, adjuvant, and palliative settings.