RT Book, Section A1 Reyes, Jorge A2 Ziegler, Moritz M. A2 Azizkhan, Richard G. A2 Allmen, Daniel von A2 Weber, Thomas R. SR Print(0) ID 1100431786 T1 Intestine Transplantation T2 Operative Pediatric Surgery, 2e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-162723-8 LK accesssurgery.mhmedical.com/content.aspx?aid=1100431786 RD 2024/03/28 AB Isolated intestinal transplantation is indicated for patients with permanent intestinal failure whose liver, including portal pressures and other systemic organs are normal. Outcomes are very good with 1-year patient and graft survivals approaching 90% and 80%, respectively.Combined intestine–liver transplantation is indicated if intestinal failure is accompanied by end-stage liver disease or severe portal hypertension (cholestasis, hypersplenism, coagulopathy). Outcomes remain favorable with about a 70% patient and graft 1-year survivals.A discouraging and as yet unexplained outcome is the fall-off of patient and graft survival at 10 years for both isolated intestine as well as intestine–liver transplants.The progressive development of newer improved immunosuppressive strategies has diminished the frequency of organ rejection and graft versus host disease which may lower long-term complication rates such as vascular, gastrointestinal, infectious, and lymphoproliferative disorders.