RT Book, Section
A1 Long, Eric
A1 Chung, Dai H.
A2 Ziegler, Moritz M.
A2 Azizkhan, Richard G.
A2 Allmen, Daniel von
A2 Weber, Thomas R.
SR Print(0)
ID 1100439256
T1 Neuroblastoma
T2 Operative Pediatric Surgery, 2e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-162723-8
LK accesssurgery.mhmedical.com/content.aspx?aid=1100439256
RD 2024/04/18
AB As  the  second  most  frequent  solid  cancer  of  childhood,  neuroblastoma  remains  an  enigmatic  tumor  with  a  dismal  outcome  for  advanced  stage  disease.Patient  age  and  tumor  stage  at  the  time  of  diagnosis  are  the  2  most  important  variables  contributing  to  neuroblastoma  progression  and  relapse.Neuroblastoma  stage  is  not  only  dependent  on  tumor  location  but  also  the  presence  of  nodal  and/or  metastatic  disease  along  with  patient  risk  factors.The  operative  goal  in  neuroblastoma  treatment  is  complete  tumor  removal  of  both  the  primary  tumor  and  its  adjacent  involved  lymph  nodes  (for  stage  I  and  II  disease).  There  may  also  be  considerable  value  in  the  cytoreductive  removal  of  the  maximum  tumor  burden  that  is  both  safe  and  feasible  in  more  advanced  stage  disease.Surgical  resection  is  not  recommended  in  stage  IV-S  disease  where  the  neuroblastoma  is  prone  to  spontaneous  regression.Multimodal  therapy-operation,  chemotherapy  and  irradiation  is  key  for  neuroblastoma  treatment  depending  on  patient  age,  disease  stage,  response  to  therapy,  and  tumor  relapse.  The  treatment  goal  remains  both  local  control,  metastatic  control,  and  the  prevention  of  relapse.