RT Book, Section
A1 Doherty, Gerard M.
SR Print(0)
ID 58096698
T1 Patent Ductus Arteriosus (PDA)
T2 Quick Answers Surgery
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 
LK accesssurgery.mhmedical.com/content.aspx?aid=58096698
RD 2024/04/19
AB •  A  congenital  heart  lesion  that  increases  pulmonary  artery  (PA)  blood  flow•  Results  in  left-to-right  shunt,  results  in  lung  infection,  pulmonary  vascular  congestion,  PA  hypertension,  right  heart  failure,  pulmonary  vasoconstriction,  pulmonary  vascular  obstructive  disease•  Eisenmenger  syndrome:  Increased  pulmonary  hypertension  such  that  left-to-right  shunt  ceases  and  shunt  becomes  right-to-left,  requiring  heart-lung  transplant•  Inhaled  nitric  oxide,  oxygen,  or  IV  tolazoline  reverses  PA  vasoconstriction•  PA  band  is  palliative  and  can  reduce  PA  flow  to  alleviate  RV  failure  and  progression  of  pulmonary  hypertension•  Ductus  arteriosus  normal  component  of  fetal  circulation  connecting  main  PA  to  aorta  distal  to  left  subclavian  artery•  In  utero,  ductus  carries  60%  of  ventricular  output,  patency  maintained  by  high  flow,  prostaglandins  (from  placenta),  low  oxygen  tension•  At  birth,  increased  pulmonary  resistance,  prostaglandin  level  decrease,  increased  oxygen  tension  causes  duct  closure•  Closure  occurs  between  1  and  3  days•  Closure  does  not  always  occur•  Causes  left-to-right  shunt,  heart  failure,  and  pulmonary  hypertension•  Associated  with  other  anomalies•  May  limit  flow  to  systemic  organs