RT Book, Section A1 Doherty, Gerard M. SR Print(0) ID 58095608 T1 Non-Hodgkin Lymphoma T2 Quick Answers Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN LK accesssurgery.mhmedical.com/content.aspx?aid=58095608 RD 2024/11/05 AB • The diagnosis of non-Hodgkin lymphoma encompasses a wide spectrum of lymphoid-derived tumors• More than 10 distinct tumor subtypes with variable biologic behavior• Non-Hodgkin lymphoma may originate from B cells, T cells, or histiocytes• In contrast to Hodgkin lymphoma, lymph node tumor involvement is more likely to spread in a noncontinous fashion in non-Hodgkin lymphoma• Prognosis and treatment is more dependent on the grade and type of malignancy in contrast to the importance of clinical stage in Hodgkin lymphoma• Functionally separated into low-grade and high-grade groups• 33% of cases arise outside of the lymph nodes: oropharynx, paranasal sinuses, thyroid, GI tract, liver, testicles, skin, bone marrow, and CNS• Most common extranodal site is the stomach, accounting for 50% of all GI lymphomas• Most accepted classification system is the Revised European-American Lymphoma (REAL) classification