RT Book, Section A1 Doherty, Gerard M. SR Print(0) ID 58094558 T1 Melanoma T2 Quick Answers Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN LK accesssurgery.mhmedical.com/content.aspx?aid=58094558 RD 2024/10/03 AB • Predominately a disease of fair-skinned people• Only 15% of melanomas develop in preexisting nevi, the remainder arise de novo• Most important prognostic factors include: -Vertical height of melanoma-Sentinel lymph node status-Number of positive lymph nodes-Presence of metastatic disease• Melanoma typically metastasizes by the lymphatic route in a predictable and orderly fashion• 4 histologic categories of melanoma:-Superficial spreading, 70% of cases-Nodular melanoma, 15% of cases-Lentigo maligna melanoma, 4-10% of cases-Acral lentiginous melanoma, 2-8% of cases• Melanoma most commonly metastasizes to the lungs, liver, and brain but can also involve the bone, adrenals, heart, and bowel