RT Book, Section A1 Doherty, Gerard M. SR Print(0) ID 58112293 T1 Hepatic Failure, Acute T2 Quick Answers Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN LK accesssurgery.mhmedical.com/content.aspx?aid=58112293 RD 2024/04/20 AB • Acute hepatic injury causes sudden loss in hepatocytes due to toxins, ischemia, or inflammatory reaction to liver• Fulminant hepatic failure defined as onset of encephalopathy within 8 weeks (9-24 weeks for subfulminant) after onset of acute hepatocellular injury• Etiologies include: -Hepatitis viruses-Cytomegalovirus (CMV)-Epstein-Barr virus (EBV)-Varicella-Herpesvirus-Toxins (acetaminophen, isoniazid most common)-Ischemia-Fatty liver of pregnancy-Reye syndrome-Wilson disease-Lymphoma-Hereditary metabolic disorders