RT Book, Section
A1 Doherty, Gerard M.
SR Print(0)
ID 58111436
T1 Goiter, Simple or Nontoxic (Diffuse & Multinodular)
T2 Quick Answers Surgery
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 
LK accesssurgery.mhmedical.com/content.aspx?aid=58111436
RD 2024/04/24
AB •  May  be  a  diffuse  or  a  multinodular  goiter•  May  be  physiologic  or  pathophysiologic-Physiologic  occurs  during  puberty,  menses,  or  pregnancy-Pathophysiologic  is  due  to  iodine-deficiency,  congenital  defect  in  thyroid  hormone  production,  or  goitrogenic  foods  or  drugs•  Generally  assumed  to  be  compensatory  response  to  inadequate  thyroid  hormone  production•  Thyroid  growth  immunoglobulins  may  also  be  important•  Food  goitrogens  include  isothiocyanate  and  goitrin  (in  milk  products)•  Drugs  implicated  as  goitrogens  include:-Lithium-p-Aminosalicylic  acid-Aminoglutethimide-Sulfonamides-Phenylbutazone•  Congenital  determined  failures  in  thyroid  hormone  metabolism  include  iodine  transport  defects,  abnormal  secretion  of  iodoproteins,  and  thyroid  hormone  resistance  syndromes