RT Book, Section A1 Doherty, Gerard M. SR Print(0) ID 58107898 T1 Colorectal Adenocarcinoma T2 Quick Answers Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN LK accesssurgery.mhmedical.com/content.aspx?aid=58107898 RD 2024/10/10 AB • Colorectal cancer second leading cause of cancer deaths (after lung)• Adenocarcinoma accounts for 95% of malignant colorectal tumors• Genetic predisposition in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (HNPCC)• Conditions predisposing to colorectal cancer -Ulcerative colitis-Crohn colitis-Schistosomal colitis-Exposure to radiation-Presence of ureterocolostomy• Possible dietary influences-High caloric intake-High saturated fat intake-Decreased dietary calcium-Decreased fiber intake• Carcinogenesis multi-step process involving dysfunction of tumor suppressor genes, including APC, DCC, P53• Distribution of colorectal cancer-25% right colon-10% transverse colon-15% left colon-20-50% rectosigmoid colon• Spreads through direct extension, hematogenously, lymph nodes, transperitoneal, intraluminal• Synchronous lesions occur in 3-5%