RT Book, Section
A1 Harvey, Adrian
A1 Berber, Eren
A2 Morita, Shane Y.
A2 Dackiw, Alan P. B.
A2 Zeiger, Martha A.
SR Print(0)
ID 6163699
T1 Chapter 18. Gastrinoma
T2 McGraw-Hill Manual: Endocrine Surgery
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160645-5
LK accesssurgery.mhmedical.com/content.aspx?aid=6163699
RD 2024/04/19
AB In  1955,  Zollinger  and  Ellison1  described  two  patients  with  jejunal  ulceration,  gastric  acid  hypersecretion,  and  a  non-β  pancreatic  islet  cell  tumor.  The  diagnostic  triad  of  gastric  acid  hypersecretion,  recurrent  peptic  ulceration  in  the  setting  of  adequate  therapy,  and  a  non-β  islet  cell  tumor  of  the  pancreas  was  proposed  for  the  syndrome  that  now  bears  their  names.  The  subsequent  development  of  a  sensitive  radioimmunoassay  resulted  in  the  identification  of  gastrin  overproduction  as  the  underlying  mechanism  for  this  syndrome.