RT Book, Section A1 Chambers, Anthony J. A1 Pasieka, Janice L. A2 Morita, Shane Y. A2 Dackiw, Alan P. B. A2 Zeiger, Martha A. SR Print(0) ID 6162969 T1 Chapter 11. Parathyroid Carcinoma T2 McGraw-Hill Manual: Endocrine Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160645-5 LK accesssurgery.mhmedical.com/content.aspx?aid=6162969 RD 2024/03/29 AB Carcinoma of the parathyroid gland is a rare endocrine malignancy, accounting for only 0.005% of all cancer registrations in the US National Cancer Database (NCDB).1 Using information from the Surveillance, Epidemiology and End Results (SEER) database, the incidence in the United States is estimated to be 5.73 per 10 million population, increasing by 60% from 1988 to 2003.2 Parathyroid cancer accounts for 0.5% to 1% of cases of primary hyperparathyroidism (PHPT) in series from Western nations and 2.8 to 5% of cases in Japan.3–6 It affects males and females equally and is evenly distributed within different socioeconomic and racial groups in the NCBD.1 The mean age of diagnosis of parathyroid cancer is 47 to 56 years, and 73% of cases occur in patients older than age 45 years.1,2