RT Book, Section A1 Callender, Glenda G. A1 Hu, Mimi I. A1 Evans, Douglas B. A1 Perrier, Nancy D. A2 Morita, Shane Y. A2 Dackiw, Alan P. B. A2 Zeiger, Martha A. SR Print(0) ID 6162569 T1 Chapter 6. Medullary Thyroid Carcinoma T2 McGraw-Hill Manual: Endocrine Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160645-5 LK accesssurgery.mhmedical.com/content.aspx?aid=6162569 RD 2024/03/28 AB Medullary thyroid carcinoma (MTC) is uncommon and accounts for only 5% of all thyroid cancers. MTC was first described in 1959 as a "peculiar" thyroid cancer with nonfollicular histology, amyloid-containing stroma, and a high incidence of lymph node metastases.1 MTC arises from the parafollicular, or calcitonin-secreting, C cells of the thyroid gland. C cells are neural crest cells that are derived embryologically from the ultimobranchial bodies and migrate to the thyroid gland. They are found throughout the thyroid but often concentrate in the uppermost third of the thyroid lobes; therefore, MTC usually originates in this region2 (Figure 6-1).