RT Book, Section
A1 Yip, Linwah
A1 Carty, Sally E.
A2 Morita, Shane Y.
A2 Dackiw, Alan P. B.
A2 Zeiger, Martha A.
SR Print(0)
ID 6162389
T1 Chapter 5. Follicular Thyroid Carcinoma and Oncocytic (Hürthle Cell) Carcinoma
T2 McGraw-Hill Manual: Endocrine Surgery
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160645-5
LK accesssurgery.mhmedical.com/content.aspx?aid=6162389
RD 2024/04/20
AB A  normal  human  thyroid  gland  contains  20  to  30  million  spherical  follicles  lined  with  follicular  epithelial  cells  filled  with  colloid  and  stores  a  3  months'  supply  of  thyroid  hormone.1  Among  the  several  differentiated  thyroid  cancers  that  originate  from  thyroid  follicular  cells,  10%  to  15%  are  follicular  thyroid  carcinomas  (FTCs)  and  3%  to  5%  are  oncocytic  (Hürthle)  cell  carcinomas  (HCCs).2  Recent  studies  suggest  that  FTC  may  represent  only  5%  of  differentiated  thyroid  cancer  in  geographical  regions  with  well-supplemented  iodine  diets.  In  iodine-deficient  regions,  however,  FTC  may  account  for  up  to  25%  to  40%  of  thyroid  carcinomas.3  In  contrast,  HCC  may  be  more  common  in  areas  with  iodine-rich  diets.4  The  mean  age  at  presentation  is  higher  for  HCC  (55  years)  than  for  FTC  (48  years).  In  most  reports,  both  disorders  are  approximately  twofold  more  common  in  women  than  men.5