RT Book, Section
A1 Bedrosian, Isabelle
A2 Kuerer, Henry M.
SR Print(0)
ID 6414923
T1 Chapter 65. The Concept of Prophylactic Mastectomy
T2 Kuerer's Breast Surgical Oncology
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160178-8
LK accesssurgery.mhmedical.com/content.aspx?aid=6414923
RD 2024/04/18
AB The  discovery  of  the  BRCA1  and  BRCA2  mutation  identifies  a  group  of  nearly  homogeneous  patients  at  substantially  increased  risk  of  breast  cancer.  The  risk  of  breast  cancer  by  age  70  in  BRCA1  mutation  carriers  is  estimated  to  range  from  44%  to  78%  and  for  BRCA2  mutation  carriers  from  31%  to  56%.1,2  Bilateral  prophylactic  mastectomy  (BPM)  is  thus  an  important  consideration  for  this  population.  Alternative  approaches  that  have  been  investigated  include  frequent  surveillance  that  includes  the  use  of  breast  magnetic  resonance  imaging  (MRI)  and  chemoprevention  using  tamoxifen.