RT Book, Section A1 Garreau, Jennifer R. A1 Giuliano, Armando E. A2 Kuerer, Henry M. SR Print(0) ID 6414498 T1 Chapter 62. Sentinel Lymph Node Biopsy T2 Kuerer's Breast Surgical Oncology YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160178-8 LK accesssurgery.mhmedical.com/content.aspx?aid=6414498 RD 2024/03/29 AB The sentinel node (SN) concept as currently applied to breast cancer and melanoma is predated by the idea that a single lymph node can reflect the tumor status of an entire lymphatic basin. Famous examples include the Virchow node (left supraclavicular node to which gastric cancer spreads), the Sister Mary Joseph node (an umbilical lymph node that represents metastatic intra-abdominal spread), the Delphian node of the thyroid, and the Cloquet node of the groin.1 The concept of the SN technique as first described by Cabanas in 1977 for use in squamous cell carcinoma of the penis was based on detailed penile lymphangiographic studies that demonstrated consistent drainage of the penile lymphatics into a node located near the saphenous/femoral vein junction.2 When this so-called SN was negative for tumor, metastasis to other ilioinguinal lymph nodes did not occur. Cabanas therefore postulated that the status of the SN could be used to decide whether or not regional lymphatic clearance was necessary. Although multiple studies have since found that a fixed-location SN is an unreliable indicator of nodal status in penile cancer, this work paved the way for mapping the SN in patients with solid cancers that drain via the lymphatics.