RT Book, Section
A1 Bartelink, Harry
A1 Meijnen, Philip
A1 Straver, Marieke
A1 Rutgers, Emiel
A2 Kuerer, Henry M.
SR Print(0)
ID 6413009
T1 Chapter 45. The EORTC Experience: From DCIS to Locally Advanced Breast Cancer
T2 Kuerer's Breast Surgical Oncology
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160178-8
LK accesssurgery.mhmedical.com/content.aspx?aid=6413009
RD 2024/04/18
AB The  European  Organization  for  Research  and  Treatment  of  Cancer  (EORTC)  Breast  Group  and  the  Radiotherapy  Group  successfully  completed  several  clinical  trials  that  included  thousands  of  patients  with  the  goal  of  improving  outcomes  by  evaluating  different  approaches  in  the  locoregional  treatment  of  breast  cancer.  These  trials  addressed  the  need  for  and  feasibility  of  alternative  or  more  aggressive  treatment  regimens  and  new  ways  to  predict  therapeutic  outcomes.  For  ductal  carcinoma  in  situ  (DCIS),  the  contribution  of  radiotherapy  in  achieving  local  control  was  examined.  For  stage  I  and  II  breast  cancer,  mastectomy  was  compared  with  breast-conserving  therapy.  This  was  followed  by  a  trial  in  which  2  different  dose  levels  of  irradiation  were  tested  (ie,  is  an  extra  boost  dose  required  after  whole-breast  irradiation?).  Reduction  of  morbidity  is  the  aim  of  the  After  Mapping  of  the  Axilla  Radiotherapy  or  Surgery  (AMAROS)  trial  comparing  axillary  lymph  node  dissection  with  axillary  irradiation  in  patients  with  proven  axillary  metastases  in  the  sentinel  nodes.  For  locally  advanced  breast  cancer,  the  contribution  of  hormonal  therapy  and  chemotherapy  was  investigated.  Finally,  the  possibility  of  predicting  treatment  outcomes  and  therefore  individualizing  treatment  regimens  is  explored  in  ongoing  trials  incorporating  genomic  profiles.  A  selection  of  the  EORTC  breast  cancer  trials  is  presented  in  this  overview,  followed  by  some  of  the  new  studies  and  suggestions  for  future  research.