RT Book, Section A1 Aoki, Fred Y. A2 Hall, Jesse B. A2 Schmidt, Gregory A. A2 Wood, Lawrence D.H. SR Print(0) ID 2289585 T1 Chapter 45. Principles of Antimicrobial Therapy and the Clinical Pharmacology of Antimicrobial Drugs T2 Principles of Critical Care, 3e YR 2005 FD 2005 PB The McGraw-Hill Companies PP New York, NY SN 9780071416405 LK accesssurgery.mhmedical.com/content.aspx?aid=2289585 RD 2023/12/03 AB Rational antibiotic use requires the most specific diagnosis that can be made, knowledge of commonly used antimicrobial agents, and appropriate monitoring of therapy.Antimicrobial prophylaxis against bacterial infections is indicated in selected patients undergoing surgical procedures and in those with cardiac valvular disease.When suspected infection threatens life or major organ function, antimicrobial therapy should be directed at all infectious possibilities of more than trivial probability until the results of definitive investigations are available.Knowledge of the clinical pharmacology of antibiotics commonly prescribed in the intensive care unit is essential for the intensivist.