RT Book, Section A1 Gottlieb, Danielle A1 Mayer, Jr., John E. A2 Cohn, Lawrence H. SR Print(0) ID 55931220 T1 Chapter 69. Tissue Engineering for Cardiac Valve Surgery T2 Cardiac Surgery in the Adult, 4e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-163310-9 LK accesssurgery.mhmedical.com/content.aspx?aid=55931220 RD 2024/09/18 AB Tissue engineering is a developing science, comprising elements of engineering and biology, whose aim is to build replacement tissues de novo from individual cellular and structural components. The impetus for our work on tissue engineered cardiovascular structures arises from the need to replace cardiovascular tissues that failed to develop normally during embryogenesis or have become dysfunctional as a consequence of disease. In pediatric patients, the cardiovascular structures most often afflicted by congenital anomalies are the cardiac valves and great vessels.