RT Book, Section
A1 Ravindranathan, Deepak
A1 Gaddh, Manila
A2 Nazzal, Munier
A2 Blebea, John
A2 Osman, Mohamed F.
SR Print(0)
ID 1200675836
T1 Thrombosis and Hemostasis
T2 Vascular and Endovascular Surgery: Clinical Diagnosis and Management
YR 2024
FD 2024
PB McGraw Hill
PP New York, NY
SN 9781260462715
LK accesssurgery.mhmedical.com/content.aspx?aid=1200675836
RD 2024/04/25
AB The  coagulation  system  is  comprised  of  both  pro-coagulant  and  anticoagulant  factors  and  serves  an  important  function  of  maintaining  the  integrity  of  the  circulatory  system  in  the  body.  Under  normal  homoeostatic  conditions,  the  balance  between  the  body’s  coagulation  pathway  and  natural  anticoagulants  maintains  blood  in  a  state  to  allow  unobstructed  flow  through  the  blood  vessels.  When  there  is  a  breach  in  the  vasculature,  the  coagulation  pathway  is  activated  and  fibrin  clot  is  formed  through  a  physiological  process  called  hemostasis.  Disorders  of  hemostasis  can  result  in  excessive  or  abnormal  bleeding.  On  the  other  hand,  activation  of  the  coagulation  pathway  within  intact  blood  vessels  leads  to  pathological  (as  opposed  to  physiological)  clotting  or  thrombosis.  Thrombi  can  form  in  veins  and/or  arteries  with  possibly  different  mechanisms  leading  to  thrombosis  in  these  different  vascular  settings.