RT Book, Section
A1 Gefen, Ashley M.
A1 Sethna, Christine B.
A2 Molmenti, Ernesto Pompeo
SR Print(0)
ID 1194188762
T1 Pediatric Kidney Transplant Rejection
T2 Molmenti’s Kidney and Pancreas Transplantation: Operative Techniques and Medical Management, 2e
YR 2023
FD 2023
PB McGraw Hill
PP New York, NY
SN 9781260474275
LK accesssurgery.mhmedical.com/content.aspx?aid=1194188762
RD 2024/04/24
AB Definition:  A  recipient’s  immune  response  to  foreign  antigens  expressed  by  the  donor  that  if  unresolved  will  lead  to  graft  lossIncidence:According  to  Organ  Procurement  Transplant  Network  (OPTN)  and  Scientific  Registry  of  Transplant  Recipients  (SRTR),  in  the  2016–2017  cohort,  incidence  of  acute  rejection  within  1  year  was  11.4%  overall.1According  to  the  North  American  Pediatric  Renal  Transplant  Cooperative  Study  (NAPRTICS),  in  the  2012–2017  cohort,  probability  rate  of  first  acute  rejection  within  1  year  was  12.7%  for  living  donors  and  13.2%  for  deceased  donors.2Significance:According  to  NAPRTICS,  chronic  rejection  and  acute  rejection  are  the  leading  causes  of  graft  failure  in  children.2  Therefore  prevention  as  well  as  early  diagnosis  and  treatment  are  important  in  improving  long-term  outcomes.3From  2008  to  2017,  21.3%  and  16.4%  of  index  graft  failures  were  secondary  to  chronic  and  acute  rejection,  respectively.2