RT Book, Section
A1 Weinstein, Jay
A1 Reimundes, Ezequiel Rodríguez
A1 Enríquez, Natalia Beatriz
A2 Molmenti, Ernesto Pompeo
A2 Santibañes, Martin de
A2 Santibañes, Eduardo de
SR Print(0)
ID 1180108572
T1 Vaccinations
T2 Liver Transplantation: Operative Techniques and Medical Management
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260462517
LK accesssurgery.mhmedical.com/content.aspx?aid=1180108572
RD 2024/04/25
AB Infectious  diseases  are  a  major  cause  of  morbidity  and  mortality  in  patients  with  chronic  liver  disease,  both  before  and  after  liver  transplantation.  Impaired  humoral  and  cellular  immunity  in  these  patients  is  attributable  to  liver  disease  itself  but  also  to  immunosuppressive  agents.1–10  Active  immunization  is  an  effective  way  to  protect  transplant  recipients  against  certain  infectious  agents.  Patients  should  be  immunized  against  common  infections  such  as  pneumococci  and  influenza  as  soon  as  chronic  liver  disease  is  diagnosed.11–14  Vaccination  against  hepatitis  A  and  B  virus  is  also  recommended  for  these  patients  who  are  vulnerable  to  viral  coinfection.  Furthermore,  infections  can  contribute  to  rejection  of  the  transplanted  organ  and  to  the  subsequent  development  of  certain  types  of  cancers.  Following  transplantation,  the  risk  for  infectious  diseases  increases  and  the  serologic  response  to  vaccination  decreases  due  to  immunosuppressive  agents.  For  this  reason,  efforts  should  be  made  to  vaccinate  patients  early  in  the  course  of  liver  disease.