RT Book, Section
A1 Pyrsopoulos, Nikolaos T.
A1 Kutner, Matthew
A2 Molmenti, Ernesto Pompeo
A2 Santibañes, Martin de
A2 Santibañes, Eduardo de
SR Print(0)
ID 1180107636
T1 Primary Biliary Cholangitis: A Review
T2 Liver Transplantation: Operative Techniques and Medical Management
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260462517
LK accesssurgery.mhmedical.com/content.aspx?aid=1180107636
RD 2024/04/25
AB Primary  biliary  cholangitis  (PBC),  previously  known  as  primary  biliary  cirrhosis,  is  a  rare  chronic  inflammatory  autoimmune  cholestatic  liver  disease  that  generally  affects  middle-aged  women.  It  is  the  most  common  chronic  cholestatic  liver  disease  in  adults  in  the  United  States.  The  disease  is  a  T-lymphocyte–mediated  chronic  destructive  cholangitis  with  elevated  serum  levels  of  anti–mitochondrial  autoantibodies  (AMAs).  The  name  change  reflects  the  fact  that  cirrhosis  occurs  only  in  the  late  stage  and  therefore  does  not  accurately  characterize  patients  with  early-stage  disease.  In  this  chapter,  we  will  review  the  epidemiology,  pathophysiology,  clinical  features,  and  diagnostic  approach,  as  well  as  treatment  modalities.