RT Book, Section
A1 Moran, Benjamin
A1 Tisherman, Samuel A.
A2 Feliciano, David V.
A2 Mattox, Kenneth L.
A2 Moore, Ernest E.
SR Print(0)
ID 1175137452
T1 Postinjury Inflammation and Organ Dysfunction
T2 Trauma, 9e
YR 2020
FD 2020
PB McGraw Hill
PP New York, NY
SN 9781260143348
LK accesssurgery.mhmedical.com/content.aspx?aid=1175137452
RD 2024/04/25
AB KEY  POINTSMultiple  organ  failure  (MOF)  is  defined  as  dysfunction  of  greater  than  one  organ  system.Although  multiple  scoring  systems  of  MOF  exist  (Marshall,  Sequential  Organ  Failure  Assessment,  Denver),  there  is  no  gold  standard.MOF  accounts  for  approximately  50%  of  delayed  deaths  in  trauma.The  pulmonary,  cardiac,  and  renal  systems  are  affected  first,  usually  within  3  days,  followed  later  by  derangements  in  hepatic  function  (>3  days).Fifty  percent  of  MOF  mortality  occurs  within  3  days,  with  80%  of  mortality  occurring  within  7  days.Traumatic  injury  and  resuscitation  from  hemorrhagic  shock  result  in  proinflammatory  and  anti-inflammatory  responses,  which  affect  multiple  organ  systems  and  can  contribute  to  sequential  organ  dysfunction.Prevention  of  MOF  is  directed  at  early  resuscitation,  avoidance  of  hypotension,  protective  lung  ventilation,  renal  protection,  and  prevention  of  secondary  infection.