RT Book, Section A1 Atay, Scott M. A1 Antonoff, Mara B. A2 Sugarbaker, David J. A2 Bueno, Raphael A2 Burt, Bryan M. A2 Groth, Shawn S. A2 Loor, Gabriel A2 Wolf, Andrea S. A2 Williams, Marcia A2 Adams, Ann SR Print(0) ID 1170416649 T1 Malignant Primary Anterior Mediastinal Tumors T2 Sugarbaker’s Adult Chest Surgery, 3e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260026931 LK accesssurgery.mhmedical.com/content.aspx?aid=1170416649 RD 2021/03/05 AB The anterior mediastinal compartment plays host to a number of unique pathologies, both benign and malignant. In many circumstances, the tumors may be quite large prior to detection, whereupon extrinsic compression of other mediastinal structures leads to significant symptomatology. Alternatively, small-volume disease may be seen incidentally when cross-sectional imaging is performed for alternate and unrelated symptoms. Last, a number of disease processes of the anterior mediastinum manifest secondary to biochemical activity in the form of paraneoplastic/immunologic syndromes. Whatever the presentation, accurate delineation of the specific underlying disease process is essential to determining the appropriate treatment strategy.