RT Book, Section A1 Cho, Michael H. A1 Fanta, Christopher H. A2 Sugarbaker, David J. A2 Bueno, Raphael A2 Burt, Bryan M. A2 Groth, Shawn S. A2 Loor, Gabriel A2 Wolf, Andrea S. A2 Williams, Marcia A2 Adams, Ann SR Print(0) ID 1170412596 T1 Overview of Chronic Obstructive Pulmonary Disease T2 Sugarbaker’s Adult Chest Surgery, 3e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260026931 LK accesssurgery.mhmedical.com/content.aspx?aid=1170412596 RD 2024/04/24 AB Chronic obstructive pulmonary disease (COPD) is defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD)1 as persistent, usually progressive, airflow limitation associated with an enhanced inflammatory response, generally in response to noxious stimuli, such as cigarette smoking. COPD is one of the few major chronic, noninfectious diseases with a rising burden; it is now the third leading cause of death in the United States.2 Worldwide, an increasing prevalence of cigarette smoking, exposure to substances such as biomass fuel, a reduction in other causes of early mortality, and an aging population have led to an increase in the global burden of COPD; from 1990 to 2015, the prevalence of COPD increased by more than 40%.3