RT Book, Section
A1 Gomez, Daniel R.
A1 Heymach, John V.
A1 Swisher, Stephen G.
A2 Sugarbaker, David J.
A2 Bueno, Raphael
A2 Burt, Bryan M.
A2 Groth, Shawn S.
A2 Loor, Gabriel
A2 Wolf, Andrea S.
A2 Williams, Marcia
A2 Adams, Ann
SR Print(0)
ID 1170410848
T1 Role of Surgery in Oligometastatic NSCLC
T2 Sugarbaker’s Adult Chest Surgery, 3e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260026931
LK accesssurgery.mhmedical.com/content.aspx?aid=1170410848
RD 2024/04/24
AB The  definition  of  oligometastatic  non–small-cell  lung  cancer  (NSCLC)  has  historically  been  based  on  the  number  of  disease  sites.  However,  this  number  has  varied  substantially  in  the  literature,  ranging  from  a  solitary  metastasis  to  up  to  five  lesions.  In  fact,  these  relatively  crude  definitions  belie  a  broader  biologic  state  that  extends  from  locally  advanced  disease  to  uncontrollable  systemic  disease  burden.  The  unique  state  of  metastases  was  proposed  by  Ralph  Weichselbaum  and  Samuel  Hellman  in  their  landmark  1995  review,1  which  has  since  been  updated  to  incorporate  more  recent  supporting  data.2  The  authors  apply  the  “seed  and  soil”  hypothesis  to  propose  that  during  the  multiple  stages  of  systemic  spread,  including  altered  cell  adhesion,  survival  in  the  circulation,  and  seeding/propagation  in  a  distant  site,  any  disruption  in  this  process  could  lead  to  a  more  limited  metastatic  state.