RT Book, Section A1 Rodríguez, María A1 Wee, Jon O. A2 Sugarbaker, David J. A2 Bueno, Raphael A2 Burt, Bryan M. A2 Groth, Shawn S. A2 Loor, Gabriel A2 Wolf, Andrea S. A2 Williams, Marcia A2 Adams, Ann SR Print(0) ID 1170408114 T1 Endoscopic Techniques in Antireflux Surgery T2 Sugarbaker’s Adult Chest Surgery, 3e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260026931 LK accesssurgery.mhmedical.com/content.aspx?aid=1170408114 RD 2024/10/15 AB Gastroesophageal reflux disease (GERD) is one of the most prevalent diseases that we meet in daily practice, and its prevalence continues to rise.1,2 If left untreated or improperly managed, GERD can lead to esophagitis, esophageal strictures, aspiration, pneumonia, vocal cold inflammation and subsequent hoarseness, pulmonary dysfunction, Barrett esophagus, and esophageal cancer.2 Proton pump inhibitors (PPIs) have been for many years the principal medical treatment of GERD, but unfortunately between 20% and 30% of patients with erosive esophagitis and up to 40% of patients with nonerosive GERD have no or limited response to PPIs, even when their dose is doubled.3 There is also the concern for potential adverse effects of long-term treatment with PPIs including Clostridium difficile infection, bone fractures, hypomagnesemia and higher incidence of chronic kidney disease in susceptible individuals.4–6