RT Book, Section
A1 Rodríguez, María
A1 Wee, Jon O.
A2 Sugarbaker, David J.
A2 Bueno, Raphael
A2 Burt, Bryan M.
A2 Groth, Shawn S.
A2 Loor, Gabriel
A2 Wolf, Andrea S.
A2 Williams, Marcia
A2 Adams, Ann
SR Print(0)
ID 1170408114
T1 Endoscopic Techniques in Antireflux Surgery
T2 Sugarbaker’s Adult Chest Surgery, 3e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260026931
LK accesssurgery.mhmedical.com/content.aspx?aid=1170408114
RD 2024/04/19
AB Gastroesophageal  reflux  disease  (GERD)  is  one  of  the  most  prevalent  diseases  that  we  meet  in  daily  practice,  and  its  prevalence  continues  to  rise.1,2  If  left  untreated  or  improperly  managed,  GERD  can  lead  to  esophagitis,  esophageal  strictures,  aspiration,  pneumonia,  vocal  cold  inflammation  and  subsequent  hoarseness,  pulmonary  dysfunction,  Barrett  esophagus,  and  esophageal  cancer.2  Proton  pump  inhibitors  (PPIs)  have  been  for  many  years  the  principal  medical  treatment  of  GERD,  but  unfortunately  between  20%  and  30%  of  patients  with  erosive  esophagitis  and  up  to  40%  of  patients  with  nonerosive  GERD  have  no  or  limited  response  to  PPIs,  even  when  their  dose  is  doubled.3  There  is  also  the  concern  for  potential  adverse  effects  of  long-term  treatment  with  PPIs  including  Clostridium  difficile  infection,  bone  fractures,  hypomagnesemia  and  higher  incidence  of  chronic  kidney  disease  in  susceptible  individuals.4–6