RT Book, Section
A1 Feng, Xin-Hua
A1 Lin, Xia
A1 Li, Xinran
A1 Yu, Juehua
A1 Nemunaitis, John
A1 Brunicardi, F. Charles
A2 Brunicardi, F. Charles
A2 Andersen, Dana K.
A2 Billiar, Timothy R.
A2 Dunn, David L.
A2 Kao, Lillian S.
A2 Hunter, John G.
A2 Matthews, Jeffrey B.
A2 Pollock, Raphael E.
SR Print(0)
ID 1164309321
T1 Molecular Biology, The Atomic Theory of Disease, and Precision Surgery
T2 Schwartz's Principles of Surgery, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259835353
LK accesssurgery.mhmedical.com/content.aspx?aid=1164309321
RD 2024/09/18
AB Key  Points  The  biologic  sciences  have  developed  drastically  in  the  last  66  years  after  the  uncovering  of  DNA  structure  by  Watson  and  Crick.  The  completion  of  the  human  genome  sequence  in  2003  represents  a  great  milestone  in  modern  science.  The  technology  emerging  from  molecular  and  cellular  biology  has  revolutionized  the  understanding  of  disease  and  will  radically  transform  the  practice  of  surgery.  The  use  of  genetically  modified  mouse  models  and  cell  lines  using  gene  therapy  and  RNA  interference  therapy  has  greatly  contributed  to  the  understanding  of  the  molecular  basis  for  human  diseases  and  targeted  therapies.  The  sequencing  of  each  individual’s  genome  has  the  potential  to  improve  the  predication,  prevention,  and  targeted  treatment  of  disease,  resulting  in  precision  medicine  and  surgery.  Fast-developing  targeted  genome  editing  tools  like  the  CRISPR-Cas9  system  greatly  facilitate  biomedical  research  in  native  conditions  and  have  shown  their  potential  in  the  treatment  of  genetic  diseases,  including  cancers,  with  a  high  degree  of  personalization  and  precision.  The  use  of  functional  genomics  and  modern  molecular  analyses  will  facilitate  the  discovery  of  actionable  genes  to  guide  choice  of  care,  including  precision  surgery.