RT Book, Section
A1 Nazzal, Munier
A1 Osman, Mohamed F.
A1 Albeshri, Heitham
A1 Abbas, Darren B.
A1 Angel, Carol A.
A2 Brunicardi, F. Charles
A2 Andersen, Dana K.
A2 Billiar, Timothy R.
A2 Dunn, David L.
A2 Kao, Lillian S.
A2 Hunter, John G.
A2 Matthews, Jeffrey B.
A2 Pollock, Raphael E.
SR Print(0)
ID 1164307640
T1 Wound Healing
T2 Schwartz's Principles of Surgery, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259835353
LK accesssurgery.mhmedical.com/content.aspx?aid=1164307640
RD 2024/04/19
AB Key  PointsWound  healing  is  a  complex  cellular  and  biochemical  cascade  that  leads  to  restitution  of  integrity  and  function.All  tissues  heal  by  similar  mechanisms,  and  the  process  undergoes  phases  of  inflammation,  cellular  migration,  proliferation,  matrix  deposition,  and  remodeling.Factors  that  impede  normal  healing  include  local,  systemic,  and  technical  conditions  that  the  surgeon  must  take  into  account.Clinically,  excess  healing  can  be  as  significant  a  problem  as  impaired  healing;  genetic,  technical,  and  local  factors  play  a  major  role.Optimal  outcome  of  acute  wounds  relies  on  complete  evaluation  of  the  patient  and  of  the  wound  and  application  of  best  practices  and  techniques.Antibiotics  should  be  used  only  in  the  presence  of  infection;  colonization  and  contamination  does  not  mean  there  is  infection.Dressing  should  facilitate  the  major  changes  taking  place  during  healing  to  produce  an  optimally  healed  wound  and  take  into  consideration  the  comorbid  conditions  associated  with  chronic  wounds.Cellular  and  tissue-based  products  are  additional  measures,  and  these  products  might  accelerate  the  rate  of  healing  but  will  not  replace  basic  wound  care.Chronic  wounds  have  a  decrease  in  oxygen  supply  to  the  wound,  which  contributes  to  delayed  healing;  oxygen  therapy  might  aid  in  the  healing  of  certain  types  of  wounds.Biofilm  is  the  term  used  for  the  bacterial  growth  on  a  chronic  wound  that  is  encapsulated  by  a  protective  layer  made  up  of  the  host  and  bacterial  proteins;  this  layer  makes  it  difficult  to  heal  chronic  wounds  and  control  infection.