RT Book, Section A1 Clancy, Thomas E. A2 Zinner, Michael J. A2 Ashley, Stanley W. A2 Hines, O. Joe SR Print(0) ID 1160045358 T1 Management of Acute Pancreatitis T2 Maingot's Abdominal Operations, 13e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071843072 LK accesssurgery.mhmedical.com/content.aspx?aid=1160045358 RD 2024/03/28 AB Acute pancreatitis can range from a mild, self-limiting ­process that responds to supportive care to severe disease with multiple organ failure and high mortality. Its incidence is ­increasing,1 and pancreatitis is one of the most common causes of hospital admission for gastrointestinal illness.2 Although most patients experience minor episodes characterized by mild parenchymal edema without organ dysfunction, response to conservative management, and ­complete recovery,3 approximately 20% to 25% of patients develop clinically severe acute pancreatitis. More severe episodes may progress to pancreatic necrosis, systemic inflammatory response ­syndrome (SIRS), multiorgan failure, clinical deterioration, and even death.4 Historically, mortality has been up to 15% in the setting of necrotizing pancreatitis and as high as 30% with infected pancreatic necrosis.5 Recent years have seen advances in the classification and management of acute pancreatitis including evidence-based guidelines and a notable shift toward nonoperative management of even the most severe cases of infected pancreatic necrosis.