RT Book, Section A1 Thompson, Callie M. A1 Maier, Ronald V. A2 Moore, Ernest E. A2 Feliciano, David V. A2 Mattox, Kenneth L. SR Print(0) ID 1147414727 T1 Management of Shock T2 Trauma, 8e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071847292 LK accesssurgery.mhmedical.com/content.aspx?aid=1147414727 RD 2024/03/29 AB Shock is defined as the inadequate delivery of oxygen to tissues leading to cellular dysfunction and injury. In 1872 Gross described shock as a “rude unhinging of the machinery of life.”1 Although this definition is less than precise, to this day it illustrates the physiologic derangements of decompensated shock. Significant hypoperfusion and cellular injury may occur despite normal systemic blood pressure, so equating shock with hypotension and cardiovascular collapse is a vast oversimplification and results in delayed recognition of early shock, when intervention is most effective at preventing end-organ dysfunction.