RT Book, Section A1 Geurts, Jennifer A1 Evans, Douglas B. A1 Tsai, Susan A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145764665 T1 Molecular Genetics of Pancreatic Neoplasms and Inherited Pancreatic Cancer Syndromes T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145764665 RD 2024/10/15 AB Cancer is fundamentally a genetic disease that develops when alterations in multiple genes result in dysregulation of a select number of cellular pathways and processes. In the last decade, rapid advances in nucleotide sequencing and bioinformatic technology have led to an expansion of information obtained from the sequencing of cancer genomes. Sequencing of pancreatic cancer (PC) genomes as well as premalignant lesions of the pancreas has deepened our understanding of tumorigenesis and identified potential novel therapeutic targets. Although PC has generally been associated with acquired genetic mutations, a small proportion of PCs may be due to inherited PC syndromes. In this chapter, we focus on the current understanding of proposed critical genes and affected pathways that have been shown to be important in sporadic and hereditary PCs.