RT Book, Section
A1 Fairweather, Mark
A1 Raut, Chandrajit P.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145763228
T1 Gastrointestinal Stromal Tumors
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK accesssurgery.mhmedical.com/content.aspx?aid=1145763228
RD 2024/04/18
AB Gastrointestinal  stromal  tumor  (GIST)  is  a  rare  malignancy  of  mesenchymal  origin.  The  true  incidence  of  GIST  has  historically  been  underestimated  as  these  tumors  were  commonly  misclassified  as  leiomyomas,  leiomyosarcomas,  and  leiomyoblastomas.1  The  term  gastric  stromal  tumor  was  first  proposed  in  1983  to  describe  gastric  wall  tumors  that  lacked  the  ultrastructural  features  of  smooth  muscle  cells  and  the  immunohistochemical  characteristics  of  Schwann  cells.2  Mazur  and  Clark2  examined  28  gastric  wall  tumors  that  were  originally  classified  by  light  microscopy  as  leiomyomas  or  leiomyosarcomas  and,  using  electron  microscopy,  determined  that  some  of  these  tumors  lacked  features  expected  in  cells  derived  from  smooth  muscle.  Additionally,  using  immunohistochemistry  to  identify  the  neuroectoderm  marker  S-100,  they  found  that  the  majority  of  tumors  failed  to  show  evidence  of  a  nerve  sheath  origin.  They  postulated  that  this  subset  of  tumors  that  did  not  appear  from  a  smooth  muscle  origin  or  peripheral  nerve  origin  may  arise  from  the  myenteric  nervous  system.