RT Book, Section A1 Bischof, Danielle A. A1 Efron, Jonathan E. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145762701 T1 Treatment of Locally Advanced Colorectal Cancer T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145762701 RD 2024/10/05 AB In the United States, rectal cancer is diagnosed in approximately 40,000 individuals annually.1 Although definitions vary, locally advanced rectal cancer generally refers to patients with T3/T4 disease and/or positive lymph nodes.2 In patients with locally advanced rectal cancer, treatment with surgery alone results in substantial risk of local recurrence; therefore, multimodality therapy is recommended.