RT Book, Section A1 Poultsides, George A. A1 Norton, Jeffrey A. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145761811 T1 Prophylactic Gastrectomy For Inherited Gastric Cancer T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145761811 RD 2024/03/28 AB Gastric cancer is the fourth most common malignancy worldwide and the second most common cause of cancer-related death.1 Histologically, gastric cancer may be classified as either of the diffuse type or of the intestinal type. The intestinal type is linked to environmental risk factors and advanced age. The diffuse type (typically associated with signet ring cell histology and/or the clinical picture of linitis plastica in advanced stages) occurs in younger patients and can have a hereditary component. Partly due to a significant decrease in the incidence of the more common intestinal type, the overall incidence of gastric cancer has decreased. However, the incidence of diffuse gastric cancer has either increased or remained stable. Approximately 10% of gastric cancer cases demonstrate familial clustering, and 1% to 3% meet the criteria for hereditary diffuse gastric cancer (HDGC).2,3