RT Book, Section A1 Murthy, Rashmi K. A1 Valero, Vicente A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145760855 T1 Overview of Systemic Therapy T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145760855 RD 2024/03/28 AB Breast cancer is the most common cancer in women and it is estimated that one in eight women in the United States will develop breast cancer in their lifetime. The American Cancer Society reported that in 2013 an estimated 232,340 new cases of invasive disease and 39,620 breast cancer deaths would occur.1 Every year more than 40,000 women die from breast cancer, making it the second leading cause of cancer-related deaths in women. Only lung cancer accounts for more cancer deaths in women. Historically, the increase in breast cancer incidence was thought to be a reflection of changes in reproductive patterns, such as delayed childbearing, no breast feeding, and giving birth to fewer children, which are recognized as risk factors. Since the early 1980s, the incidence of breast cancer among postmenopausal women was steadily rising due to improved detection with the widespread use of mammography. The rates stabilized in the late 1990s and then started to decrease; it has been hypothesized that the decline occurred due to a reduced use of hormone replacement therapy following the 2002 publication of the Women’s Health Initiative randomized trial results.2,3 In contrast the incidence of breast cancer in younger women has remained stable. Although breast cancer is a rare disease in young women, it is the most common cancer occurring in the age group. When it occurs in women <35 years, it brings forth unique clinical challenges for the clinician and personal challenges for the patient, especially when associated with pregnancy.4,5 With a rapidly aging population in the United States, the number of breast cancer is expected to increase over the next 20 years. Fortunately, breast cancer mortality rates have declined continuously since 1990, despite the larger and older U.S. population.6 Part of this decline in mortality is attributable to early diagnosis; however, a large part is due to advances in cancer treatment and the incorporation of adjuvant systemic therapy.