RT Book, Section A1 Sorensen, Meredith J. A1 Gauger, Paul G. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145758331 T1 Gastrinoma T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145758331 RD 2024/10/15 AB Gastrinomas are gastrin-secreting neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that result in hypergastrinemia. This leads to excessive gastric acid secretion and the resultant clinical manifestations, such as refractory PUD (with sequelae like bleeding, perforation, and obstruction), gastroesophageal reflux disease, and diarrhea.1,2 Gastrinomas are associated with multiple endocrine neoplasia type 1 (MEN-1) in about 25% of cases and occur sporadically the other three-quarters of the time.2,3