RT Book, Section
A1 Yip, Linwah
A1 Stang, Michael T.
A1 McCoy, Kelly L.
A1 Carty, Sally E.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145757471
T1 Medullary Thyroid Cancer
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK accesssurgery.mhmedical.com/content.aspx?aid=1145757471
RD 2024/04/18
AB Medullary  thyroid  cancer  (MTC)  is  a  well-differentiated  neuroendocrine  tumor  arising  from  the  calcitonin-producing  parafollicular  cells,  also  known  as  C  cells.  C  cells  are  derived  from  neural  crest  cells  that  form  the  ultimobranchial  bodies  of  the  fourth  and  fifth  branchial  pouches.  During  thyrogenesis,  the  ultimobranchial  bodies  fuse  with  the  thyroid  laterally  and  as  a  result,  C  cells  are  concentrated  in  the  upper  poles  of  the  thyroid.  In  addition  to  calcitonin,  MTC  may  secrete  carcinoembryonic  antigen  (CEA),  adrenocorticotrophic  hormone  (ACTH),  and  occasionally  somatostatin.  Symptoms  related  to  hormone  hypersecretion  such  as  diarrhea,  flushing,  or  Cushing’s  syndrome  may  be  the  presenting  manifestation  and  are  usually  representative  of  advanced  disease.