RT Book, Section
A1 Noureldine, Salem I.
A1 Tufano, Ralph P.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145757305
T1 Locally Advanced and Aggressive Thyroid Cancer
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK accesssurgery.mhmedical.com/content.aspx?aid=1145757305
RD 2024/04/23
AB Thyroid  cancer  is  considered  to  be  the  most  common  endocrine  malignancy,  with  estimated  new  cases  exceeding  60,000  in  2013.1  Although  most  patients  who  present  with  thyroid  cancer  have  well-differentiated  intrathyroidal  tumors  that  carry  an  excellent  prognosis,  these  tumors  have  a  distinct  tendency  for  multifocal  involvement  and  regional  lymph  node  metastasis.  The  adverse  prognostic  factors  in  thyroid  cancer  have  been  well-established  and  include  patient  age,  tumor  histology,  primary  tumor  size,  extrathyroidal  extension,  and  distant  metastasis.2  The  greatest  negative  impact  on  prognosis,  from  a  surgical  standpoint,  is  extrathyroidal  extension.3  Up  to  15%  of  patients  with  differentiated  thyroid  cancer  (DTC)  exhibit  aggressive  behavior,  hallmarked  by  extrathyroidal  extension,  treatment  resistance,  and  increased  mortality.3,4