RT Book, Section A1 Balch, Charles M. A1 Balch, Glen C. A1 Thompson, John F. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145755839 T1 Biopsy and Definitive Excision of Primary Cutaneous Melanomas T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145755839 RD 2024/04/20 AB A skin lesion that is suspicious for melanoma is best removed by excisional biopsy with a 1- to 2-mm clinical lateral margin and a deep margin into the subcutaneous fat, underneath all epithelial appendageal structures.1 This can be performed on most lesions up to 1.5 cm in diameter (Fig. 13-1). The biopsy scar should be oriented to be compatible with a subsequent wide local excision should the lesion prove to be melanoma. On the extremities a longitudinal or oblique incision is preferred. On the trunk or the head and neck the biopsy should be oriented parallel to the skin lines. A full-thickness biopsy should be undertaken in order to accurately interpret the maximum tumor thickness, the presence or absence of ulceration, and the level of invasion.1