TY - CHAP M1 - Book, Section TI - Overview of Chronic Obstructive Pulmonary Disease A1 - Cho, Michael H. A1 - Fanta, Christopher H. A2 - Sugarbaker, David J. A2 - Bueno, Raphael A2 - Colson, Yolonda L. A2 - Jaklitsch, Michael T. A2 - Krasna, Mark J. A2 - Mentzer, Steven J. A2 - Williams, Marcia A2 - Adams, Ann PY - 2015 T2 - Adult Chest Surgery, 2e AB - Chronic obstructive pulmonary disease (COPD) is defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD)1 as persistent, usually progressive airflow limitation associated with an enhanced inflammatory response, generally in response to noxious stimuli, such as cigarette smoking. COPD is one of the few major diseases with a rising burden; it is now the third leading cause of death in the United States.2 Worldwide, an increasing prevalence of cigarette smoking, other exposures such as to biomass fuel, a reduction in other causes of early mortality, and an aging population are expected to lead to an increase in the global burden of COPD, and its rise from the fifth to the fourth most common cause of mortality (Fig. 97-1).3 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/24 UR - accesssurgery.mhmedical.com/content.aspx?aid=1105843841 ER -