TY - CHAP M1 - Book, Section TI - Liver Transplantation A1 - Tiao, Greg M. A2 - Ziegler, Moritz M. A2 - Azizkhan, Richard G. A2 - Allmen, Daniel von A2 - Weber, Thomas R. PY - 2014 T2 - Operative Pediatric Surgery, 2e AB - Though liver transplantation remains a technically challenging operative procedure and patients are complex in their perioperative management, the use of whole organ, reduced size, split liver, and even living donors has resulted in an overall improved patient survival approaching 90% for infants and children alike. These techniques have also reduced waiting list mortality.The indications for liver transplantation have become somewhat more liberal and have improved outcomes for children with hepatoblastoma, a pediatric disease with a here-to-fore dismal prognosis.Improved immunosuppression includes multiple drugs and in some centers even steroid-free immunosuppression. These protocols have limited the adverse impact of allograft rejection while minimizing the complications of immunosuppression including infection and PTLD. Chronic rejection awaits a better solution. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/15 UR - accesssurgery.mhmedical.com/content.aspx?aid=1100440171 ER -