TY - CHAP M1 - Book, Section TI - Wound Healing A1 - Sømme, Stig A2 - Ziegler, Moritz M. A2 - Azizkhan, Richard G. A2 - Allmen, Daniel von A2 - Weber, Thomas R. PY - 2014 T2 - Operative Pediatric Surgery, 2e AB - Wound healing, like the body's response to injury, undergoes the three phases of inflammation, proliferation, and remodeling.Inflammatory cell infiltration is a key step in wound healing, stimulated in part by endothelial cells, monocytes and cytokines.The wound's fibrin plug brings collagen synthesizing fibroblasts to the wound, the cells that also stimulate the production of mucopolysaccharides.“Scarless” fetal wound healing may relate to an altered inflammatory response, collagen composition and hyaluronic acid composition when compared to adult wound healing and scar formation.Negative pressure is an important therapeutic adjunct for the treatment of delayed healing wounds. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/19 UR - accesssurgery.mhmedical.com/content.aspx?aid=1100431940 ER -