TY - CHAP M1 - Book, Section TI - Thoracic Aortic Dissection A1 - Doherty, Gerard M. PY - 2010 T2 - Quick Answers Surgery AB - • Often lethal event• Degeneration of aortic media is hallmark of disease• Pathogenesis controversial 1. Medial degeneration leads to rupture of vasa vasorum2. Intimal tears allows blood to shear weakened media• Location of intimal tear: Ascending aorta, 62%; arch, 10%; isthmus, 16%; rest in distal aorta• Risk factors include: -Hypertension-Atherosclerosis-Iatrogenic injury (catheter or open heart surgery)-Closed chest trauma-Marfan syndrome-Aortic coarctation SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=58102459 ER -