TY - CHAP M1 - Book, Section TI - Multiple Endocrine Neoplasia Type 1 (MEN 1) A1 - Doherty, Gerard M. PY - 2010 T2 - Quick Answers Surgery AB - • Also known as Wermer syndrome• Characterized by tumors of the parathyroid, anterior pituitary, and pancreas• Tumors may develop synchronously or metachronously, may be benign or malignant, and may be hyperplasia, adenomas, or carcinoma• Pancreatic tumors include functioning and nonfunctioning islet tumors such as gastrinoma, insulinoma, glucagonoma, VIPoma, somatostatinoma, pancreatic polypeptide tumors (PPomas)• Other tumors in MEN 1 can include adrenocortical tumors, thymic or bronchial carcinoid tumors, multiple lipomas, cutaneous angiofibromas and collagenomas• Syndrome is transmitted as autosomal dominant trait• Most common mutation is in the menin gene on 11q13• Trait has 100% penetrance but variable expressivity SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=58095230 ER -