TY - CHAP M1 - Book, Section TI - Goiter, Simple or Nontoxic (Diffuse & Multinodular) A1 - Doherty, Gerard M. PY - 2010 T2 - Quick Answers Surgery AB - • May be a diffuse or a multinodular goiter• May be physiologic or pathophysiologic-Physiologic occurs during puberty, menses, or pregnancy-Pathophysiologic is due to iodine-deficiency, congenital defect in thyroid hormone production, or goitrogenic foods or drugs• Generally assumed to be compensatory response to inadequate thyroid hormone production• Thyroid growth immunoglobulins may also be important• Food goitrogens include isothiocyanate and goitrin (in milk products)• Drugs implicated as goitrogens include:-Lithium-p-Aminosalicylic acid-Aminoglutethimide-Sulfonamides-Phenylbutazone• Congenital determined failures in thyroid hormone metabolism include iodine transport defects, abnormal secretion of iodoproteins, and thyroid hormone resistance syndromes SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/10 UR - accesssurgery.mhmedical.com/content.aspx?aid=58111436 ER -