TY - CHAP M1 - Book, Section TI - Chapter 94. Whole-Breast Radiation Following Breast-Conserving Therapy for Noninvasive and Invasive Cancers A1 - Moran, Meena S. A2 - Kuerer, Henry M. PY - 2010 T2 - Kuerer's Breast Surgical Oncology AB - Breast-conserving therapy (BCT), consisting of surgical removal of the primary tumor followed by radiation therapy to the intact breast, is now considered a standard treatment approach for early-stage breast cancer. Increasing numbers of patients are becoming eligible for breast conservation after the diagnosis of breast cancer, due to improvements in early detection and patient awareness. In addition, patients presenting with larger tumors that previously would have required mastectomy may now be eligible for BCT using neoadjuvant chemotherapy to downsize the tumor, followed by local excision and radiation. Data from multiple randomized prospective studies have demonstrated equivalent long-term survival outcomes for BCT compared to mastectomy and the benefit of adding adjuvant radiation therapy after conservative surgery. Furthermore, there are numerous retrospective single-institutional series that support the use of conservative surgery and radiation therapy in early-stage breast cancer. This chapter will discuss the indications and validity of postoperative, whole-breast radiation therapy for noninvasive and invasive cancer, and will address special considerations and future directions for radiation therapy as a component of breast conservation therapy for early-stage breast cancer. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesssurgery.mhmedical.com/content.aspx?aid=6417933 ER -