TY - CHAP M1 - Book, Section TI - Chapter 59. Intraductal Therapy A1 - Goulet Jr., Robert J. A1 - Tsangaris, Theodore N. A1 - Love, Susan M. A2 - Kuerer, Henry M. PY - 2010 T2 - Kuerer's Breast Surgical Oncology AB - The epithelium of the breast ductal system is the site of origin for nearly all breast cancers.1,2 The intraductal environment and the significance of the secretions produced within the human mammary gland have been debated for centuries. The recognition of the role of carcinogens in the production of malignancies led to a renewed interest in the ductal anatomy and physiology in the 20th century. Today, the combination of technological enhancement providing direct and indirect access to the luminal milieu and advances in cellular methodology that hold the promise of reliable diagnostic and predictive markers of breast cancer are driving investigators to pursue a ductal approach to breast cancer diagnosis and therapy that will be preemptive and accurate with less toxicity and breast disfigurement. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/10 UR - accesssurgery.mhmedical.com/content.aspx?aid=6414173 ER -