TY  - CHAP
M1  - Book, Section
TI  - Necrotizing Soft Tissue Infections
A1  - Urbina, Tomas
A1  - Prost, Nicolas de
A2  - Schmidt, Gregory A.
A2  - Kress, John P.
A2  - Douglas, Ivor S.
PY  - 2023
T2  - Hall, Schmidt and Wood’s Principles of Critical Care, 5<sup>th</sup> Edition
AB  - KEY  POINTSNecrotizing  soft  tissue  infections  (NSTIs)  are  life-threatening  soft  tissue  infections  defined  by  a  necrotizing  component  involving  any  or  all  the  layers  of  the  soft  tissue  compartment.NSTIs  of  the  extremities,  mainly  of  the  lower  limb,  represent  the  most  common  condition.Most  NSTIs  involve  polymicrobial  pathogens;  In  20%  to  30%  of  cases,  NSTIs  are  monomicrobials  and  primarily  involve  Group  A  streptococcus  (GAS).The  “gold  standard”  to  confirm  the  diagnosis  of  NSTI  is  surgical  exploration.In  patients  with  sepsis  or  septic  shock,  imaging  (CT  scan  and/or  MRI)  must  never  delay  surgery.The  key  early  therapeutic  interventions  required  are  broad-spectrum  antibiotics  and  debridement  surgery.The  mainstem  of  empiric  treatment  is  a  broad-spectrum  beta-lactam  with  additional  aminoglycosides  in  case  of  septic  shock.  Clindamycin  should  be  added  in  case  of  documented  or  suspected  (GAS)  infection.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/10/05
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1201806178
ER  -