TY  - CHAP
M1  - Book, Section
TI  - Primary Biliary Cholangitis: A Review
A1  - Pyrsopoulos, Nikolaos T.
A1  - Kutner, Matthew
A2  - Molmenti, Ernesto Pompeo
A2  - Santibañes, Martin de
A2  - Santibañes, Eduardo de
PY  - 2021
T2  - Liver Transplantation: Operative Techniques and Medical Management
AB  - Primary  biliary  cholangitis  (PBC),  previously  known  as  primary  biliary  cirrhosis,  is  a  rare  chronic  inflammatory  autoimmune  cholestatic  liver  disease  that  generally  affects  middle-aged  women.  It  is  the  most  common  chronic  cholestatic  liver  disease  in  adults  in  the  United  States.  The  disease  is  a  T-lymphocyte–mediated  chronic  destructive  cholangitis  with  elevated  serum  levels  of  anti–mitochondrial  autoantibodies  (AMAs).  The  name  change  reflects  the  fact  that  cirrhosis  occurs  only  in  the  late  stage  and  therefore  does  not  accurately  characterize  patients  with  early-stage  disease.  In  this  chapter,  we  will  review  the  epidemiology,  pathophysiology,  clinical  features,  and  diagnostic  approach,  as  well  as  treatment  modalities.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesssurgery.mhmedical.com/content.aspx?aid=1180107636
ER  -